Chi. White Sox at Chi. Cubs 2:20 PM ET
a trend the club wants to prolong in their Rivalry Weekend opener Friday afternoon against the visiting South Siders.
Cleveland at Cincinnati 5:10 PM ET
In 11 years as Cleveland's manager, Terry Francona earned 921 wins, led the team to six playoff appearances and came within one game of claiming the 2016 World Series title.
Pittsburgh at Philadelphia 6:45 PM ET
Left-hander Ranger Suarez will try to build on what manager Rob Thomson called a "fantastic" start when he takes the mound Friday night against the visiting Pittsburgh Pirates in the opener of a three-game series.
NY Mets at NY Yankees 7:05 PM ET
Toward the end of last season and into a postseason run where the New York Yankees made their first World Series appearance since 2009, the affection between the fans and All-Star outfielder Juan Soto was evident and highlighted by daily "re-sign Soto" chants.
Washington at Baltimore 7:05 PM ET
The Washington Nationals scored on Nasim Nunez's two-out infield single in the ninth inning to claim a 4-3 victory against the host Baltimore Orioles on Friday night to open a three-game series.
Washington at Baltimore 7:05 PM ET
Two struggling teams meet when the Washington Nationals visit the Baltimore Orioles for a three-game interleague series.
Detroit at Toronto 7:07 PM ET
The Detroit Tigers aim to extend their three-game winning streak and enhance their American League-best record when they visit the Toronto Blue Jays on Friday night.
Atlanta at Boston 7:10 PM ET
A battle of ace left-handers is on tap for Friday night as Garrett Crochet's Boston Red Sox face old friend Chris Sale and the Atlanta Braves in the opener of a three-game weekend series in Boston.
Tampa Bay at Miami 7:10 PM ET
Since April 30, Kyle Schwarber has seven home runs and Aaron Judge has six.
St. Louis at Kansas City 7:40 PM ET
The St. Louis Cardinals enter rivalry weekend filled with confidence, while still amid their most successful stretch of the season.
Houston at Texas 8:05 PM ET
The Texas Rangers will look to build on their season-best winning streak when they host the Houston Astros on Friday in the second of a four-game American League West series in Arlington, Texas.
Minnesota at Milwaukee 8:10 PM ET
The Minnesota Twins are accumulating victories at a near-record pace.
Colorado at Arizona 9:40 PM ET
The Arizona Diamondbacks will get their first view at the new-look Colorado Rockies this weekend, although the Rockies have looked a lot like their old selves since owner Dick Monfort fired manager Bud Black on Sunday.
Seattle at San Diego 9:40 PM ET
In tossing 14 1/3 scoreless innings during his first two MLB starts, San Diego Padres right-hander Stephen Kolek has at the very least staked his claim on a rotation spot down the road, even though Yu Darvish is about to come off the injured list.
LA Angels at LA Dodgers 10:10 PM ET
Two years and another MVP later, the overwhelming intrigue when it comes to the Los Angeles Dodgers facing the freeway-adjacent Los Angeles Angels still is Shohei Ohtani taking on his former team.
Athletics at San Francisco 10:15 PM ET
rather than Bay Area -- rivals for the first time when the early-season surprises open a three-game interleague series in San Francisco on Friday night.