NY Mets at Cincinnati 12:35 PM ET
The New York Mets and Cincinnati Reds have split the first two of their three-game set, but managed to conduct some business off the field that could fill a need for each team. The Mets traded pitcher Matt Harvey to the Reds in exchange for catcher Devin Mesoraco, who could start for visiting New York in Wednesday afternoon's rubber match.
Cleveland at Milwaukee 1:10 PM ET
The Milwaukee Brewers can move into first place in the National League Central when they host the struggling Cleveland Indians for the finale of their two-game interleague set on Wednesday afternoon. The Brewers received homers from Travis Shaw and pitcher Brent Suter in the first three innings of the series opener on Tuesday and held on for a 3-2 victory to improve to 5-2 over their last seven contests.
Detroit at Texas 2:05 PM ET
Adrian Beltre returned to the lineup in style but couldn't prevent the Texas Rangers from losing for the seventh time in 10 games. Beltre looks to help Texas win the deciding contest of its three-game series against the visiting Detroit Tigers on Wednesday afternoon.
Pittsburgh at Chi. White Sox 2:10 PM ET
The Pittsburgh Pirates aim to continue their interleague mastery when they finish a two-game series at the Chicago White Sox on Wednesday afternoon. With a 10-6 win in Tuesday's series opener, the Pirates improved to 7-2 against the American League, giving them three more wins than any other team in the majors in interleague play.
Miami at Chi. Cubs 2:20 PM ET
The Chicago Cubs look to continue their dominance over the Miami Marlins at Wrigley Field when they try to complete a three-game home sweep on Wednesday afternoon. The Cubs have won nine of their last 10 home games against the Marlins, outscoring Miami 58-22 in those contests.
LA Angels at Colorado 3:10 PM ET
After ending April with three straight losses, the Colorado Rockies have been unbeatable thus far in May. Colorado looks to extend its month-opening winning streak to seven games when it hosts the Los Angeles Angels on Wednesday afternoon for the finale of their two-game interleague series.
Houston at Oakland 3:35 PM ET
The Houston Astros appear to have corrected themselves after a rough start to May and look to complete a series sweep when they visit the Oakland Athletics on Wednesday afternoon for the finale of their three-game set. Houston lost five of its first six contests this month but has collected 32 hits while outscoring Oakland 20-4 in the first two games of the series.
Boston at NY Yankees 7:05 PM ET
The white-hot New York Yankees have made up 7 1/2 games on the Boston Red Sox since April 20 to pull into tie for first place in the American League East. The Yankees are on a 16-1 tear -- their best 17-game stretch since 1953 -- and look to extend their winning streak to eight when they resume their three-game series against visiting Boston on Wednesday night.
Kansas City at Baltimore 7:05 PM ET
The Kansas City Royals began a six-game road trip with their best offensive showing of the season, and they’ll try to carry that momentum into the second contest of their three-game series at the Baltimore Orioles on Wednesday. The Royals smacked four home runs in a 10-run first inning Tuesday, scoring seven runs before the Orioles recorded an out en route to a 15-7 rout.
San Francisco at Philadelphia 7:05 PM ET
The Philadelphia Phillies have been taking advantage of their hitter-friendly home confines this season, highlighted by belting seven homers to win the first two contests of their four-game series versus the San Francisco Giants. The Phillies (20-15) look to tee off on right-hander Chris Stratton and the Giants (19-17) on Wednesday when the set continues at Citizens Bank Park.
Seattle at Toronto 7:07 PM ET
The Seattle Mariners continue to make themselves at home outside of the Pacific Northwest as they began their seven-game road trip with a no-hitter in the opener of their three-game series versus the Toronto Blue Jays. The Mariners (20-14) aim to add to their already impressive 12-6 road record on Wednesday when they vie for a series victory versus the Blue Jays (19-17).
Atlanta at Tampa Bay 7:10 PM ET
Ronald Acuna Jr. is the youngest player in the major leagues, and the Atlanta Braves look to finish a sweep of a two-game series at the Tampa Bay Rays on Wednesday thanks to the power from one of baseball’s rising young stars. In his 12th big-league game, the 20-year-old cranked his third homer - a 434-foot blast deep into the left-field seats - in a 1-0 Atlanta victory on Tuesday to raise his average to .320 with three homers and six RBIs in his first 50 at-bats.
Washington at San Diego 9:10 PM ET
The streaking Washington Nationals look to win for the 10th time in 11 games when they conclude their three-game series against the host San Diego Padres on Wednesday. The Nationals have won the first two games of the set by a total of seven runs after posting a 4-0 triumph on Tuesday.
Arizona at LA Dodgers 10:10 PM ET
The Los Angeles Dodgers returned home Tuesday hoping for a fresh start following a 4-7 road trip but instead lost their third straight with a 12-inning, 8-5 loss to the visiting Arizona Diamondbacks. The teams conclude their brief two-game set on Wednesday with the Dodgers’ Alex Wood facing Arizona’s Patrick Corbin.
